Glucose Fluctuation Inhibits Nrf2 Signaling Pathway in Hippocampal Tissues and Exacerbates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats.
Haiyan ChiYujing SunPeng LinJunyu ZhouJinbiao ZhangYachao YangYun QiaoDeshan LiuPublished in: Journal of diabetes research (2024)
GF aggravates cognitive impairment by inhibiting the Nrf2 signaling pathway and inducing oxidative stress and apoptosis in the hippocampal tissues.
Keyphrases
- diabetic rats
- oxidative stress
- cognitive impairment
- signaling pathway
- induced apoptosis
- pi k akt
- gene expression
- ischemia reperfusion injury
- epithelial mesenchymal transition
- dna damage
- temporal lobe epilepsy
- blood glucose
- heat shock
- cell proliferation
- type diabetes
- cell death
- adipose tissue
- weight loss
- endoplasmic reticulum stress
- high fat diet