Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration.

Juan Ignacio Jiménez-LoygorriÁlvaro Viedma-PoyatosRaquel Gómez-SintesPatricia Boya

Published in: Molecular neurodegeneration (2024)

Collectively, these data highlight a novel putative application of UA in the treatment of AMD whereby it bypasses lysosomal defects by promoting p62-dependent lysophagy to sustain proteostasis.

Keyphrases

liver failure
optical coherence tomography
diabetic retinopathy
electronic health record
respiratory failure
drug induced
machine learning
combination therapy
deep learning
extracorporeal membrane oxygenation
endoplasmic reticulum