PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways.
Anuli C UzozieEnes K ErginNina RolfJanice TsuiAmanda LorentzianSamuel S H WengLorenz NiervesTheodore G SmithC James LimChristopher A MaxwellGregor S D ReidPhilipp F LangePublished in: Journal of experimental & clinical cancer research : CR (2021)
Genomic and host factors shape protein and post-translational modification landscapes differently. This study highlights select areas of diverging biology while confirming murine patient-derived xenografts as a generally accurate model system.