Challenges in transfusion and the role of Thalidomide in E-β-Thalassemia-A case report.

Hemoglobin E-β-thalassemia is a common β-thalassemia that has a variable presentation from mild to severe life-threatening anemia. We describe such a case, who presented with severe anemia and multiple allo-antibodies. Our case illustrates the role of thalidomide in transfusion-sparing therapies in patients with transfusion-dependent thalassemia and challenges in the blood bank.