Phytolectin nanoconjugates in combination with standard antifungals curb multi-species biofilms and virulence of vulvovaginal candidiasis (VVC) causing Candida albicans and non-albicans Candida.
Jayasankari SenthilganeshShruthi KuppusamyRubini DurairajanSiva Bala SubramaniyanAnbazhagan VeerappanParamasivam NithyanandPublished in: Medical mycology (2022)
The present study focuses on exploiting the high biding affinity between the cell surface glycans present in Candida cells and the plant lectin, Jacalin. Jacalin serves as a 'Trojan Horse' wherein the lectin-coupled nanoparticles show a high efficacy when compared with the unconjugated nanoparticles. The present approach also improves the anti-biofilm activity of the antifungal drugs against drug-resistant Candida strains.
Keyphrases
- candida albicans
- drug resistant
- biofilm formation
- cell surface
- multidrug resistant
- escherichia coli
- acinetobacter baumannii
- induced apoptosis
- pseudomonas aeruginosa
- cell cycle arrest
- staphylococcus aureus
- oxidative stress
- cystic fibrosis
- antimicrobial resistance
- cell proliferation
- signaling pathway
- drug induced
- walled carbon nanotubes