Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation.
Alexandra CîrciumaruMarcelo Gomes AfonsoHeidi WähämaaAkilan KrishnamurthyMonika HanssonLinda Mathsson-AlmMárton KeszeiRagnhild StålesenLars OttossonCharlotte de VriesMiriam A ShelefVivianne MalmströmLars KlareskogAnca I CatrinaCaroline GrönwallAase HensvoldBence RethiPublished in: Biomolecules (2023)
Neutrophils can be important sources of citrullinated antigens under conditions that lead to PAD4 activation, NETosis and the extrusion of intracellular material. A substantial clonal diversity in targeting neutrophils and a high variability among individuals in neutrophil binding and osteoclast stimulation suggest that ACPAs may influence RA-related symptoms with high patient-to-patient variability.