New Alkaloids and Steroids from Hydranth of Goniopora columna corals and Their Inhibiting lung cancer cell Activities.
Guangfu FengJieyi HeQiqi LiMeng BaiKai LiuXinming LiuXiangxi YiYonghong LiuLianxiang LuoCheng-Hai GaoPublished in: Chemistry & biodiversity (2024)
A new alkaloids, aplysingoniopora A (1), and new configuration pregnane type steroid compound, 9,17-α-pregn-1,4,20-en-3-one (2), and two known pregnane type steroid compounds (3 and 4) were isolated from hydranth of Goniopora columna corals. The compounds structures and absolute configurations were determined by extensive spectroscopic analysis, MS data, single-crystal X-ray diffraction analysis and quantum chemical calculation. The anticancer effect of the compounds were explored in human non-small-cell lung cancer (NSCLC) A549 cell lines. As the results, the compound 3 and 4 induces toxicity and has proliferation inhibitory effects on A549 cells (IC 50 =58.99 μM and 58.77 μM, respectively) in vitro.
Keyphrases
- signaling pathway
- high resolution
- small cell lung cancer
- induced apoptosis
- mass spectrometry
- oxidative stress
- magnetic resonance imaging
- electronic health record
- molecular docking
- molecular dynamics
- magnetic resonance
- cell death
- cell cycle arrest
- deep learning
- molecular dynamics simulations
- artificial intelligence
- crystal structure
- energy transfer