Genetic Association and Transferability for Urinary Albumin-Creatinine Ratio as a Marker of Kidney Function in four Sub-Saharan African Populations and non-continental Individuals of African Ancestry.

Jean-Tristan Brandenburg Wenlong Carl Chen Romuald Palwende Boua Melanie Ann Govender Godfred Agongo Lisa K Micklesfield Hermann Sorgho Stephen M Tollman Gershim Asiki Felistas Mashinya Scott Hazelhurst Andrew P Morris June Fabian Michelle Ramsaynull null

Published in: medRxiv : the preprint server for health sciences (2024)

This study contributes novel insights into the genetic architecture of kidney function in SSA populations, emphasizing the need for conducting genetic research in diverse cohorts. The identified loci provide a foundation for future investigations into the genetic susceptibility to chronic kidney disease in underrepresented African populations.

Keyphrases

genome wide
chronic kidney disease
copy number
dna methylation
end stage renal disease
gene expression
peritoneal dialysis