Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest.
Sean J CooneyJelena KlawitterLudmilla KhailovaJustin RobisonJames JaggersRichard J IngScott LawsonBenjamin S FrankSuzanne Osorio LujanJesse A DavidsonPublished in: Metabolomics : Official journal of the Metabolomic Society (2021)
Our results demonstrate significant metabolic disturbances between dorsocaudal and ventral lung regions during supine mechanical ventilation with or without CPB/DHCA. CPB/DHCA also leads to metabolic differences and may have additive effects to the regional disturbances. Most pathways driving this pathology are involved in energy metabolism and the metabolism of amino acids, carbohydrates, and reduction-oxidation pathways.