Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's).
Dhaneshree Bestinee NaidooAnil Amichund ChuturgoonAlisa PhulukdareeKanive Parashiva GuruprasadKapaettu SatyamoorthyVikash SewramPublished in: BMC complementary and alternative medicine (2018)
In PBMC's and THP-1 cells, WRE proved to effectively modulate antioxidant activity, inflammatory cytokines and cell death. In THP-1 cells, WRE decreased pro-inflammatory cytokine levels, which may alleviate cancer cachexia and excessive leukaemic cell growth.