Transcriptome Profiling after Early Spinal Cord Injury in the Axolotl and Its Comparison with Rodent Animal Models through RNA-Seq Data Analysis.
Juan Carlos González-OrozcoItzel Escobedo-AvilaIván VelascoPublished in: Genes (2023)
Immune-related processes are upregulated shortly after SCI in axolotls and rodents; however, a strong immune response is more noticeable in rodents. Genes related to early development and neurogenesis are upregulated beginning in the acute stage of SCI in axolotls, while the loss of motor and sensory functions is detected only in rodents during the sub-acute period of SCI. The approach employed in this study might be useful for designing and establishing regenerative therapies after SCI in mammals, including humans.
Keyphrases
- spinal cord injury
- rna seq
- single cell
- data analysis
- liver failure
- spinal cord
- immune response
- neuropathic pain
- drug induced
- respiratory failure
- stem cells
- genome wide
- mesenchymal stem cells
- aortic dissection
- gene expression
- hepatitis b virus
- cell therapy
- intensive care unit
- extracorporeal membrane oxygenation
- subarachnoid hemorrhage
- tissue engineering