7T dynamic contrast-enhanced MRI for the detection of subtle blood-brain barrier leakage.
Lisanne P W CanjelsJacobus F A JansenMarieke van den KerkhofRobert-Jan AlersBenedikt A PoserChristopher J WigginsVeronique M M M SchifferVincent van de VenRob P W RouhlW M PalmRobert J van OostenbruggeAlbert P AldenkampChahinda Ghossein-DohaMarc E A SpaandermanWalter H BackesPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2021)
We demonstrate how a dual-time resolution DCE-MRI protocol at 7T, with administration of half the clinically used contrast agent dose, can be used for assessing subtle BBB leakage. Although the feasibility of DCE-MRI for assessing the BBB integrity at 3T is well known, we showed that a continuous sampling DCE-MRI method tailored for 7T is also capable of assessing leakage with a high sensitivity over a range of Ki values.
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