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A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.

Sunniva Todnem SakkestadHans SteinslandSteinar SkredeKristine LillebøDag Harald SkutlabergAnne Berit GuttormsenAnton ZavialovSari PaavilainenHanne SøylandMarianne SævikAstrid Rykkje HeienMarit Gjerde TellevikEileen BarryNina LangelandHalvor SommerfeltKurt Hanevik
Published in: PLoS neglected tropical diseases (2019)
ClinicalTrials.gov ClinicalTrials.gov, Project ID: NCT02870751.
Keyphrases
  • escherichia coli
  • endothelial cells
  • induced pluripotent stem cells
  • klebsiella pneumoniae
  • heat stress
  • biofilm formation
  • irritable bowel syndrome
  • staphylococcus aureus