SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo.

Bobo Wing-Yee MokMaxwell KwokHung Sing LiLowell LingAngel LaiBin YanCherie Tsz-Yiu LawChui Him YeungAnna Jinxia ZhangRachel Chun-Yee TamAnja KukicConor J CreminYajie ZhangTeng LongZhisen KangRuibang LuoKam Tong LeungAlbert M LiGrace LuiStephen Kwok-Wing TsuiJasper Fuk-Woo ChanKelvin Kai-Wang ToPaul K S ChanBryan P YanHonglin ChenEllen Ngar Yun Poon

Published in: Cell & bioscience (2024)

In this study, we reveal previously unknown differences in how different SARS-CoV-2 variants affect CMs. Omicron BA.2, which is generally thought to cause mild disease, can damage CMs in vitro and in vivo. Our study highlights the need for further investigations to define the pathogenesis of cardiac complications arising from different SARS-CoV-2 variants.

Keyphrases

sars cov
respiratory syndrome coronavirus
copy number
oxidative stress
left ventricular
single cell