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Collapse in the elderly: rivastigmine-induced heart block and a literature review of the pharmacology of acetylcholinesterase inhibitors used in Alzheimer's disease.

Olushola AlongeFahad Mujtaba IqbalElzbieta Cifonelli
Published in: BMJ case reports (2018)
Falls resulting in neck of femur fractures are common in the elderly. Often multiple comorbidities can make management and diagnosis of such a polyfactorial condition difficult, particularly with Alzheimer's dementia (AD). Indeed, poorly managed AD may contribute to falls. We present our management of an 87-year-old woman, on rivastigmine for AD, who presented with a collapse episode-attributed to rivastigmine-resulting in a neck of femur fracture. Furthermore, we perform a literature review of the pharmacology of acetylcholinesterase inhibitors and how their use in AD may contribute to bradyarrhythmias.
Keyphrases
  • community dwelling
  • case report
  • cognitive decline
  • middle aged
  • mild cognitive impairment
  • bone mineral density
  • diabetic rats
  • high glucose
  • oxidative stress
  • postmenopausal women
  • drug induced