Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding.

Chengwei LiJincai WenXiaoyan ZhanWei ShiXiu YeQing YaoSimin ChenCongyang ZhengXianlin WangXinru WenXiaohe XiaoYinghao WangZhaofang Bai

Published in: Chinese medicine (2024)

Our research indicates that TTN effectively treats ALI and autoimmune illnesses mediated by the cGAS-STING pathway by inhibiting the abnormal activation of this pathway.

Keyphrases

multiple sclerosis
signaling pathway
oxidative stress
dendritic cells
mouse model
drug induced
dna binding