Antisense Oligonucleotide Targeting Hepatic Serum Amyloid A Limits the Progression of Angiotensin II-Induced Abdominal Aortic Aneurysm Formation.
Preetha ShridasAiling JiAndrea C TrumbauerVictoria P NoffsingerLuke W MeredithFrederick C de BeerAdam E MullickNancy R WebbDennis G KarounosLisa R TannockPublished in: bioRxiv : the preprint server for biology (2023)
Plasma Serum amyloid A (SAA) levels are significantly reduced by SAA-specific antisense-oligonucleotide (SAA ASO) treatment.SAA ASO treatment significantly reduced matrix metalloprotease activities, macrophage infiltration, and elastin breaks in the abdominal aorta during the progression of AAA in obese C57BL/6J mice.Treatment with SAA ASO significantly reduced the progression of aortic dilation, thus limiting the progression of the disease.