Long-read single-cell sequencing reveals the transcriptional landscape of spermatogenesis in obstructive azoospermia and Sertoli cell-only patients.
Xiaolong WuM LuD YunS GaoFei SunPublished in: QJM : monthly journal of the Association of Physicians (2024)
We have identified total full-length transcripts in OA and NOA, and new genes were found. Furthermore, specific expressed full-length transcripts were detected, and the genomic structure of transcripts was mapped in different cell types. These findings may provide valuable information on human spermatogenesis and the treatment of male infertility.
Keyphrases
- single cell
- rna seq
- end stage renal disease
- high throughput
- endothelial cells
- chronic kidney disease
- newly diagnosed
- cell therapy
- gene expression
- peritoneal dialysis
- prognostic factors
- genome wide
- transcription factor
- adipose tissue
- dna methylation
- health information
- polycystic ovary syndrome
- combination therapy
- mesenchymal stem cells
- single molecule