COVID-19 in a mosaic trisomy 13 patient with polycystic kidney disease.
Natalie K OstHeather M MinchewAndrew GarciaHammad A GanatraPublished in: SAGE open medical case reports (2022)
Presentation, management, and outcomes of COVID-19 infections among younger patients is an area of medicine with deficits in research, likely due to the lower incidence of severe COVID-19 disease among the younger population. Management can be challenging, and clinicians often guide their decision-making based on the ever-changing protocols that are tailored mostly to the elderly population. Even more underrepresented in COVID-19 research are patients with chromosomal abnormalities and trisomy syndromes, as they appear less frequently, but have risk of increased morbidity and mortality due to underlying medical conditions. We describe a case of severe COVID-19 infection in a young patient with mosaic trisomy 13 and pre-existing polycystic kidney disease, who developed severe acute hypoxic respiratory failure and acute chronic kidney injury. The patient was provided maximal pharmacological support and her clinical course helps to shape the understanding of COVID-19 infections in the setting of chromosomal abnormalities and complex medical history.
Keyphrases
- coronavirus disease
- sars cov
- respiratory failure
- polycystic kidney disease
- case report
- healthcare
- decision making
- respiratory syndrome coronavirus
- extracorporeal membrane oxygenation
- drug induced
- end stage renal disease
- palliative care
- blood pressure
- type diabetes
- risk factors
- intensive care unit
- prognostic factors
- dna methylation
- peritoneal dialysis
- hepatitis b virus
- heart rate
- insulin resistance