Mild, Selective Ru-Catalyzed Deuteration Using D2 O as a Deuterium Source.
Pascal EiseleFranziska UllwerSven ScholzBernd PlietkerPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl2 (PPh3 )3 ] and D2 O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru-complexes under the given specific conditions.