Efficient neutralization of daratumumab in pretransfusion samples using a novel recombinant monoclonal anti-idiotype antibody.

Fleur AungJeff SpencerDavid PotterThuy-Dung PhamNaheed FarooquiKathryn R PlattRaja ZayatMelanie OliveiraRobin Smeland-WagmanEric PetersenRichard Max Kaufman

Published in: Transfusion (2022)

An anti-DARA:DARA ratio as low as 1:1 is sufficient to neutralize DARA in solution. A fixed amount of anti-DARA eliminates the anti-CD38 interference in most patient samples.

Keyphrases

multiple myeloma
solid state