Quality control of psychoactive substances in human breastmilk samples from a human milk bank by disposable pipette extraction-gas chromatography-mass spectrometry.
Wilson José Ramos Santos JúniorNayna Cândida GomesBruno Ruiz Brandão da CostaVítor Luiz Caleffo Piva BigãoBruno Spinosa de MartinisPublished in: Bioanalysis (2023)
The lack of data regarding infant exposure to drugs of abuse consumed by lactating mothers has become a major health concern. Investigating psychoactive substances and their metabolites in breastmilk is an analytical approach to estimate the rate at which drugs of abuse are excreted and how much infants are exposed to them. In this study, we have developed and validated a GC-MS method using disposable pipette tips for simultaneously extracting ten analytes from breastmilk samples obtained from a milk bank in the city of Ribeirão Preto, Brazil. All the 67 analyzed samples tested negative for all the analytes. This is the first study that has applied disposable pipette extraction to analyze drugs of abuse in breastmilk samples.
Keyphrases
- human milk
- gas chromatography mass spectrometry
- solid phase extraction
- quality control
- public health
- healthcare
- endothelial cells
- drinking water
- mental health
- low birth weight
- electronic health record
- risk assessment
- health information
- deep learning
- preterm infants
- artificial intelligence
- induced pluripotent stem cells
- human health