Evolutionary genomic analyses of canine E. coli infections identify a relic capsular locus associated with resistance to multiple classes of antimicrobials.

Kristina M Ceres Jordan D ZehrChloe MurrellJean K MilletQi SunHolly C McQuearyAlanna HortonCasey CazerKelly SamsGuillaume ReboulWilliam B AndreopoulosPatrick K MitchellRenee AndersonRebecca Franklin-GuildBrittany D CronkBryce J StanhopeClaire R BurbickRebecca WolkingLaura PeakYan ZhangRebeccah McDowallAparna KrishnamurthyDurda SlavicPrabhjot Kaur SekhonGregory H TysonOlgica CericMichael J Stanhope Laura B Goodman

Published in: Applied and environmental microbiology (2024)

antimicrobial susceptibility data from sick dogs across the US and Canada, we identified a strong multidrug resistance association with an operon that appears to have once conferred a type 1 capsule production system.

Keyphrases

escherichia coli
electronic health record
big data
genome wide
copy number
genome wide association study
gene expression
data analysis
artificial intelligence