Ganonorsterone A, a norsteroid from the medicinal fungus Ganoderma lingzhi .

Jia-Hui DuXuan ZhaoFei ZhangYan WangKun DuSi-Yi DingWei-Sheng FengZhen-Zhu Zhao

Published in: Journal of Asian natural products research (2024)

Phytochemical investigation on the fruiting bodies of the medicinal fungus Ganoderma lingzhi led to the isolation of a new norsteroid, namely ganonorsterone A ( 1 ), together with one known steroid, cyathisterol ( 2 ). The structure and absolute configuration of compound 1 were assigned by extensive analysis of MS, NMR data, and quantum-chemical calculations including electronic circular dichroism (ECD) and calculated 13 C NMR-DP4+ analysis. Bioassay results showed that compound 1 displayed moderate inhibition on NO production in RAW 264.7 macrophages.

Keyphrases

magnetic resonance
high resolution
molecular dynamics
solid state
mass spectrometry
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density functional theory
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