pH-Responsive Capsule Polymer Particles Prepared by Interfacial Photo-Cross-Linking: Effect of the Alkyl Chain Length of the pH-Responsive Monomer.

pH-responsive capsule particles have immense potential for use in various advanced fields, such as microreactors and drug delivery. Moreover, the interfacial photo-cross-linking of spherical polymer particles is a promising strategy to create various functional capsule particles. In this study, pH-responsive capsule polymer particles were prepared by interfacial photo-cross-linking with photo-reactive polymers possessing different pH-responsive monomer units of different alkyl chain lengths, namely, 2-dimethylaminoethyl methacrylate, 2-diethylaminoethyl methacrylate, and 2-diisopropylaminoethyl methacrylate. Using these different pH-responsive monomers, regulation of the controlled release properties of pH-responsive capsule particles was achieved. All capsule particles prepared from these three different polymers released encapsulated molecules under acidic conditions; however, more acidic conditions were necessary for releasing encapsulated molecules with the increasing alkyl chain length. The afforded results indicated that pH-responsive monomers of different alkyl chain lengths could be successfully employed to regulate the pH-responsive controlled release property of the capsule particles prepared by interfacial photo-cross-linking.