Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts.
Madeline UretskySylvain BouixRonald J KillianyYorghos TripodisBrett MartinJoseph PalmisanoAsim Z MianKaren BuchChad W FarrisDaniel H DaneshvarBrigid DwyerLee GoldsteinDouglas KatzChristopher J NowinskiRobert CantuNeil KowallBertrand Russell HuberRobert A SternVictor E AlvarezThor D SteinAnn McKeeJesse MezMichael L AloscoPublished in: Neurology (2021)
This study provides Class IV evidence of associations between FLAIR white matter hyperintensities, and neuropathological changes (white matter rarefaction, arteriolosclerosis, p-tau accumulation), years of American football play, and reported cognitive symptoms in symptomatic brain donors exposed to repetitive head impacts.