A series of new 5-(2-amino-5-methylthiazol-4-yl)-1,3,4-oxadiazole-2-thiol derivatives 6(a-j) were designed and synthesized with various substituted aldehydes. The chemical structures were confirmed by elemental analyses, FT-IR, (1)H NMR, and mass spectral studies. The antioxidant activity of the synthesized compounds was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl, nitric oxide, and superoxide radical scavenging assay methods. Compounds 6a, 6e, and 6c showed significant radical scavenging potential due to the presence of electron donating substituent on substituted aldehydes.
Keyphrases
- nitric oxide
- molecular docking
- high resolution
- hydrogen peroxide
- structure activity relationship
- magnetic resonance
- optical coherence tomography
- oxide nanoparticles
- nitric oxide synthase
- solid state
- computed tomography
- case control
- magnetic resonance imaging
- molecular dynamics simulations
- climate change
- dual energy
- single cell