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Multi-regulatory potency of USP1 on inflammasome components promotes pyroptosis in thyroid follicular cells and contributes to the progression of Hashimoto's thyroiditis.

Xuying ZhaoWenyu NiWenjie ZhengWenkai NiChunfeng SunYunjuan GuZhi-Feng Gu
Published in: Molecular medicine (Cambridge, Mass.) (2024)
Our study highlights a regulatory mechanism of USP1 on inflammasome activation and pyroptosis in TFCs during HT pathogenesis. These findings expand our understanding of HT and suggest that inhibiting USP1 may be a potential treatment strategy for managing HT.
Keyphrases
  • induced apoptosis
  • nlrp inflammasome
  • transcription factor
  • signaling pathway
  • cell cycle arrest
  • risk assessment
  • human health
  • cell proliferation