The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD).
Jiangfeng DuYaping QinYahong WuWenshan ZhaoWenjie ZhaiYuanming QiChuchu WangJiangfeng DuPublished in: Cell communication and signaling : CCS (2018)
The structural information from MD simulation combined with in silico mutagenesis provides guidance to design engineered PD-1 mutants to modulate the PD-1/PD-L1 pathway.