EVI5 is an oncogene that regulates the proliferation and metastasis of NSCLC cells.

Tingting CaiJieqi ZhouYuanyuan ZengWenwen DuYang ZhangTing LiuYulong FuJian-An HuangQian QianJianjie ZhuChunhua LingZeyi Liu

Published in: Journal of experimental & clinical cancer research : CR (2020)

Based on these results, we demonstrated a new post-transcriptional mechanism of EVI5 regulation via miR-486-5p and the protumoral function of EVI5 in NSCLC by interacting with Emi1 and/or TGF-β receptors, which provides a new insight into the targeted therapy of NSCLC.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
induced apoptosis
brain metastases
signaling pathway
cell cycle arrest
gene expression
oxidative stress
endoplasmic reticulum stress
cell death
heat shock
cell proliferation
pi k akt
heat stress