Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy.

Jia-Zhen WuMustafa ArdahCaroline HaikalAlexander SvanbergssonMeike DiepenbroekNishant N VaikathWen LiZhan-You WangTiago F OuteiroOmar M El-AgnafJun-Fang Teng

Published in: Translational neurodegeneration (2019)

Our data indicate that DHM and Sal B are effective in modulating α-synuclein accumulation and aggregate formation and augmenting activation of CMA, holding potential for the treatment of Parkinson's disease.

Keyphrases

signaling pathway
cell death
oxidative stress
electronic health record
endoplasmic reticulum stress
big data
heat shock
endoplasmic reticulum
combination therapy