Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy.
Jia-Zhen WuMustafa ArdahCaroline HaikalAlexander SvanbergssonMeike DiepenbroekNishant N VaikathWen LiZhan-You WangTiago F OuteiroOmar M El-AgnafJun-Fang TengPublished in: Translational neurodegeneration (2019)
Our data indicate that DHM and Sal B are effective in modulating α-synuclein accumulation and aggregate formation and augmenting activation of CMA, holding potential for the treatment of Parkinson's disease.