Low dose gamma irradiation attenuates cyclophosphamide-induced cardiotoxicity in rats: role of NF-κB signaling pathway.

Amira Abd-ElRaoufAhmed S NadaNour El-Din A MohammedHany A AmerSahar S Abd-ElRahmanRania M AbdelsalamHesham A Salem

Published in: International journal of radiation biology (2021)

Low-dose irradiation-induced amelioration is partially but not completely through canonical activation of NF-κB, and may have another atypical pathway. While telmisartan probably ameliorates NF-κB totally through canonical pathway.

Keyphrases

signaling pathway
low dose
pi k akt
high dose
lps induced
diabetic rats
high glucose
oxidative stress
nuclear factor
induced apoptosis
epithelial mesenchymal transition
radiation therapy
endothelial cells
immune response
radiation induced
inflammatory response
cell proliferation