L-Selenocysteine induced HepG-2 cells apoptosis through reactive oxygen species-mediated signaling pathway.
Kaiying ZhangJingyao SuDanyang ChenBinger LinYucan WuYibing WangJiapei LeiRuilin ZhengBing ZhuYinghua LiPublished in: Molecular biology reports (2022)
Our data suggest that L-selenocysteine may cause mitochondrial damage and subsequently stimulate ROS production. ROS can damage cellular DNA and mediate the production of Casapase-8, Bid, Bcl-2 and other proteins, affecting downstream signaling pathways, and ultimately induced apoptosis.
Keyphrases
- induced apoptosis
- oxidative stress
- reactive oxygen species
- signaling pathway
- diabetic rats
- dna damage
- endoplasmic reticulum stress
- cell death
- pi k akt
- cell cycle arrest
- high glucose
- electronic health record
- epithelial mesenchymal transition
- circulating tumor
- cell free
- big data
- drug induced
- artificial intelligence
- endothelial cells
- machine learning