Treponema pallidum Periplasmic and Membrane Proteins Are Recognized by Circulating and Skin CD4+ T Cells.
Tara B ReidCharmie GodornesVictoria L CampbellKerry J LaingLauren C TantaloAlloysius GomezThepthara N PholsenaNicole A P LiebermanTaylor R KrauseVictoria I CegielskiLauren A CulverNhi NguyenDenise Q TongKelly L HawleyAlexander L GreningerLorenzo GiacaniCaroline E CameronJulia C DombrowskiAnna WaldDavid M KoellePublished in: The Journal of infectious diseases (2024)
T. pallidum infection elicits an antigen-specific CD4+ T-cell response in blood and skin. T. pallidum-specific CD4+ T cells persist as memory in both compartments long after curative therapy. The T. pallidum antigenic targets we identified may be high-priority vaccine candidates.