A multiomic analysis to identify drivers of subclinical vascular disease in systemic lupus erythematosus.
Christopher OliveiraYenealem Temesgen-OyelakinMohammad NaqiMichael DavisFaiza NazStefania Dell'OrsoStephen BrooksSkyler KuhnTom HillXiaobai LiNidhi PatelPhilip PareMassimo GadinaSarthak GuptaNehal MehtaSarfaraz A HasniMariana J KaplanPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Blood gene expression patterns and serum proteins that associate with worse vascular phenotypes suggest dysregulated immune and metabolic pathways linked to premature CVD. Cytokines and chemokines identified in associations with arterial stiffness, inflammation and NCB in SLE may allow for characterization of new CVD biomarkers in lupus.