Quantitative trait variation in ASD probands and toddler sibling outcomes at 24 months.
Jessica B GiraultMeghan R SwansonShoba S MeeraRebecca L GrzadzinskiMark D ShenCatherine A BurrowsJason J WolffJuhi PandeyTanya St JohnAnnette EstesLonnie ZwaigenbaumKelly N BotteronHeather C HazlettStephen R DagerRobert T SchultzJohn N ConstantinoJoseph Pivennull nullPublished in: Journal of neurodevelopmental disorders (2020)
Proband ASD symptomology, indexed by the SCQ, is a predictor of familial ASD recurrence risk. While quantitative variation in social communication and restricted and repetitive behavior were not associated among sibling pairs, standardized ratings of proband language and communication explained significant variation in the same domains in the sibling at 24 months, especially among toddlers with an ASD diagnosis. These data suggest that proband characteristics can alert clinicians to areas of developmental concern for young children with familial risk for ASD.
Keyphrases
- autism spectrum disorder
- attention deficit hyperactivity disorder
- intellectual disability
- early onset
- high resolution
- healthcare
- high frequency
- mental health
- electronic health record
- palliative care
- type diabetes
- skeletal muscle
- adipose tissue
- metabolic syndrome
- big data
- clinical decision support
- machine learning
- free survival