Epigenetic induction of tumor stemness via the lipopolysaccharide-TET3-HOXB2 signaling axis in esophageal squamous cell carcinoma.

Fengkai XuZhonghe LiuRonghua LiuChunlai LuLin WangWei MaoQiaoliang ZhuHuankai ShouKunpeng ZhangYin LiYiwei ChuJie GuDi Ge

Published in: Cell communication and signaling : CCS (2020)

Lipopolysaccharide served as a tumor promotor in ESCC by inducing cancer cell stemness through the activation of a LPS-TET3-HOXB2 signaling axis, which might provide a novel therapeutic strategy for ESCC. Video Abstract.

Keyphrases

inflammatory response
stem cells
epithelial mesenchymal transition
toll like receptor
lps induced
dna methylation
immune response
anti inflammatory
signaling pathway