Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice.

Ya-Jing ZhuJing HuangRu ChenYu ZhangXin HeWen-Xin DuanYuan-Lei ZouMeng-Mei SunHui-Li SunSi-Min ChengHao-Chuan WangHao ZhangWen-Ning Wu

Published in: Journal of neuroinflammation (2024)

Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behavior in mice and the regulation of autophagy could be a valuable therapeutic strategy for the management of depression.

Keyphrases

nlrp inflammasome
oxidative stress
cell death
endoplasmic reticulum stress
signaling pathway
high fat diet induced
bipolar disorder
depressive symptoms
stress induced
metabolic syndrome
skeletal muscle
insulin resistance
sleep quality