The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions.
Daniela SorrientoMaria Rosaria RuscianoValeria ViscoAntonella FiordelisiFederica Andrea CerasuoloPaolo PoggioMichele CiccarelliGuido IaccarinoPublished in: Cells (2021)
Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.
Keyphrases
- insulin resistance
- type diabetes
- skeletal muscle
- glycemic control
- high fat diet
- cardiovascular disease
- adipose tissue
- high fat diet induced
- metabolic syndrome
- heart failure
- polycystic ovary syndrome
- blood pressure
- blood glucose
- gene expression
- left ventricular
- case control
- arterial hypertension
- coronary artery disease
- cardiac resynchronization therapy