Caesalpanins A-C, Three Dimeric Cassane Diterpenoids from the Seeds of Caesalpinia sappan L.
De-Sheng WangWei NieTing-Ting JiangLin-Fen DingLiu-Dong SongXing-De WuQin-Shi ZhaoPublished in: Chemistry & biodiversity (2020)
Three dimeric cassane diterpenoids, caesalpanins A-C, were isolated from the seeds of Caesalpinia sappan L., as well as three known compounds. Their structures were determined via analysis of 1D-, 2D-NMR, and HR-ESI-MS data. Caesalpanins A and B were the second and third compounds that presented a nitrogen-containing cassane diterpenoid dimer linked through one ether bond between C-19 and C-20'. Caesalpanin B exhibited moderate cytotoxic activity against MCF-7 cell lines with IC50 value of 29.98 μm. Caesalpanins A and B had weak inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages at 50 μm with inhibitory rate of 36.01 % and 32.93 %, respectively.
Keyphrases
- lps induced
- nitric oxide
- ms ms
- inflammatory response
- high resolution
- mass spectrometry
- magnetic resonance
- electronic health record
- multiple sclerosis
- breast cancer cells
- high intensity
- hydrogen peroxide
- big data
- nitric oxide synthase
- solid state
- machine learning
- artificial intelligence
- deep learning
- electron transfer