Strong Association of Angiotensin Converting Enzyme-2 Gene Insertion/Deletion Polymorphism with Susceptibility to SARS-CoV-2, Hypertension, Coronary Artery Disease and COVID-19 Disease Mortality.
Mohammad Muzaffar MirRashid MirMushabab Ayed Abdullah AlghamdiBadr Abdulmohsin AlsayedJaved Iqbal WaniMuffarah Hamid AlharthiAbdullah M Al-ShahraniPublished in: Journal of personalized medicine (2021)
It is concluded that ACE-DD genotype and D allele was strongly associated with increased COVID-19 patient severity. In addition, ACE I/D polymorphism were strongly associated with advanced age, diabetes and ischemic heart disease in COVID-19 patients whereas ACE-II genotype was a protective factor against the development of severe COVID-19. ACE2-DD genotype was strongly associated with increased COVID-19 mortality. Additionally, ACE2-CC and CT genotypes were strongly associated with COVID-19 severity. Therefore, our study might be useful for identifying the susceptible population groups for targeted interventions and for making relevant public health policy decisions.
Keyphrases
- sars cov
- angiotensin converting enzyme
- coronavirus disease
- angiotensin ii
- public health
- respiratory syndrome coronavirus
- coronary artery disease
- cardiovascular events
- healthcare
- blood pressure
- cardiovascular disease
- skeletal muscle
- computed tomography
- physical activity
- gene expression
- case report
- metabolic syndrome
- risk factors
- magnetic resonance imaging
- heart failure
- insulin resistance
- glycemic control
- drug delivery
- aortic valve