ZNF354C Mediated by DNMT1 Ameliorates Lung Ischemia-Reperfusion Oxidative Stress Injury by Reducing TFPI Promoter Methylation to Upregulate TFPI.

Qi ShiNana FengQingyun MaShaohua WangHuijun ZhangDayu HuangJiayuan Sun Meng Shi

Published in: Oxidative medicine and cellular longevity (2022)

ZNF354C overexpression induced proliferation and migration, as well as suppressed ROS in OGD/R-induced HUVECs, and alleviated LIRI in mice by inhibiting TFPI promoter methylation to upregulate TFPI. Therefore, ZNF354C and TFPI methylation might be promising molecular markers for LIRI therapy.

Keyphrases

dna methylation
diabetic rats
oxidative stress
genome wide
high glucose
gene expression
transcription factor
dna damage
drug induced
cell proliferation
stem cells
adipose tissue
metabolic syndrome
mesenchymal stem cells
high fat diet induced
induced apoptosis
heat shock protein
cell therapy
stress induced