Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation.
Kai LeZhiping SongJie DengXin PengJun ZhangLiang WangLu ZhouHaidi BiZhengyu LiaoZhen FengPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)
These results suggest that the neuroprotective effect of quercetin in HIBI mice is partially due to the inhibition of oxidative stress and TLR4-mediated inflammatory responses in activated microglia.
Keyphrases
- oxidative stress
- brain injury
- inflammatory response
- subarachnoid hemorrhage
- cerebral ischemia
- toll like receptor
- immune response
- diabetic rats
- neuropathic pain
- induced apoptosis
- ischemia reperfusion injury
- signaling pathway
- nuclear factor
- high fat diet induced
- metabolic syndrome
- mouse model
- type diabetes
- insulin resistance