The complexity of COVID-19 is also related to the multiple molecular pathways triggered by SARS-CoV-2, which is able to cause type I pneumocyte death, trigger intravascular coagulation, interfere with the renin-angiotensin system, dysregulate iron metabolism, ending with the insurgence of a cytokine storm which may lead to death. Old adults with obesity, hypertension, and diabetes are among the high-risk category groups more prone to SARS-CoV-2 infection. Magnesium has been reported to play a major role both in physiology and in pathology, particularly in elderly people, regulating cytotoxic functions of natural killer (NK) cells and CD8+ T lymphocytes. In spite of the absence of controlled trials, the possibility of magnesium supplementation for supportive treatment in patients with COVID-19 should be encouraged. This could be useful in all phases of the COVID-19 disease.
Keyphrases
- sars cov
- nk cells
- coronavirus disease
- respiratory syndrome coronavirus
- respiratory tract
- type diabetes
- blood pressure
- cardiovascular disease
- metabolic syndrome
- coronary artery
- insulin resistance
- weight loss
- adipose tissue
- physical activity
- high fat diet induced
- weight gain
- single molecule
- smoking cessation
- anti inflammatory