Prevention of urethral fibrosis induced by transforming growth factor beta 1 using selective Wnt/β-catenin signaling inhibitors in a rat model.

Kyung Hwa Choi Dae Keun KimA Ram KimSeung Ryeol Rhee

Published in: International journal of urology : official journal of the Japanese Urological Association (2022)

ICG-001 and PRI-724 significantly ameliorated urethral fibrosis induced by transforming growth factor beta 1 in rats. These results suggest that ICG-001 and PRI-724 can be developed as therapeutics for treating urethral stricture.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
urinary incontinence
fluorescence imaging
stem cells
cell proliferation
small molecule
liver fibrosis
photodynamic therapy
signaling pathway