Antibacterial Salinaphthoquinones from a Strain of the Bacterium Salinispora arenicola Recovered from the Marine Sediments of St. Peter and St. Paul Archipelago, Brazil.
Alison B da SilvaEdilberto R SilveiraDiego V WilkeElhton G FerreiraLeticia V Costa-LotufoMaria Conceição M TorresAlejandro Pedro AyalaWendell S CostaKirley M CanutoAlyne R de Araújo-NobreAna Jérsia AraújoJosé Delano B Marinho FilhoOtília Deusdênia Loiola PessoaPublished in: Journal of natural products (2019)
Salinaphthoquinones A-E (1-5) were isolated from a marine Salininispora arenicola strain, recovered from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the compounds were elucidated using a combination of spectroscopic (NMR, IR, HRESIMS) data, including single-crystal X-ray diffraction analysis. A plausible biosynthetic pathway for 1-5 is proposed. Compounds 1 to 4 displayed moderate activity against Staphylococcus aureus and Enterococcus faecalis with MIC values of 125 to 16 μg/mL.
Keyphrases
- staphylococcus aureus
- high resolution
- heavy metals
- magnetic resonance
- molecular docking
- polycyclic aromatic hydrocarbons
- computed tomography
- machine learning
- solid state
- biofilm formation
- escherichia coli
- electronic health record
- pseudomonas aeruginosa
- cystic fibrosis
- electron microscopy
- molecular dynamics simulations
- data analysis
- candida albicans
- dual energy