MC4R variants modulate α-MSH and setmelanotide induced cellular signaling at multiple levels.

Alejandra V Rodríguez RondónMila S WellingErica L T van den AkkerElisabeth F C van RossumElles M J BoonMieke M van HaelstPatric J D DelhantyJenny A Visser

Published in: The Journal of clinical endocrinology and metabolism (2024)

We show that these obesity-associated MC4R variants affect MC4R signaling differently, yet leading to a comparable clinical phenotype. Our results demonstrate the clinical importance of assessing the effect of MC4R variants on a range of molecular signaling mechanisms to determine their association with obesity, which may aid in improving personalized treatment.

Keyphrases

copy number
insulin resistance
metabolic syndrome
weight loss
type diabetes
gene expression
high glucose
adipose tissue
dna methylation
skeletal muscle
oxidative stress
drug induced
endothelial cells
combination therapy
stress induced