Delayed neutrophil apoptosis may enhance NET formation in ARDS.

Chao SongHaitao LiZhi MaoLing PengBen LiuFengyu LinYi LiMinhui DaiYanhui CuiYuhao ZhaoDuoduo HanLingli ChenXun HuangPinhua Pan

Published in: Respiratory research (2022)

Neutrophils with extended lifespan in ARDS usually enhance NET formation, which aggravates inflammation. Enhancing neutrophil apoptosis in ARDS can reduce the formation of NETs, inhibit inflammation, and consequently alleviate ARDS.

Keyphrases

acute respiratory distress syndrome
oxidative stress
extracorporeal membrane oxygenation
mechanical ventilation
endoplasmic reticulum stress
cell cycle arrest
cell death
intensive care unit
signaling pathway
drosophila melanogaster