Potential molecular and cellular mechanisms for adverse placental outcomes in pregnancies complicated by SARS-CoV-2 infection-A scoping review.

Janelle Y WaiEilidh M WoodKylie K HornadayDonna M Slater

Published in: PloS one (2023)

Our findings suggest that changes in the ACE2 pathway, mitochondrial dysfunction, and/or inflammatory processes may lead to placental damage observed in SARS-CoV-2 infection during pregnancy. More research is needed to understand the role of these pathways further, in addition to data collection related to trimester, severity, and strain.

Keyphrases

preterm birth
respiratory syndrome coronavirus
oxidative stress
gestational age
pregnancy outcomes
electronic health record
angiotensin ii
angiotensin converting enzyme
big data
sars cov
human health
single molecule
emergency department
coronavirus disease
risk assessment
machine learning