DNA-methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma.
Yenan WuIsabelle SeufertFawaz N Al-ShaheriRoman KurilovAndrea S BauerMehdi ManoochehriEvgeny A MoskalevBenedikt BrorsChristin TjadenNathalia A GieseThilo HackertMarkus W BüchlerJörg D HoheiselPublished in: Gut (2023)
The success of machine-learning to identify an effective marker signature documents the power of this approach. The high diagnostic accuracy of discriminating PDAC from CP could have tremendous consequences for treatment success, once the result from still a limited number of liquid biopsy samples would be confirmed in a larger cohort of patients with suspected pancreatic cancer.